Entry information
Entry name DNP_DENAN
Primary accession P28374
integrated into UniProtKB/Swiss-Prot 01 December 1992
sequence version 1 01 December 1992
entry version 46 19 January 2010
Name and origin of the protein
Protein name Natriuretic peptide
DNP
From Dendroaspis angusticeps (Eastern green mamba) (Taxon ID: 8618)
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis
Keywords Direct protein sequencing; Disulfide bond; Ionic channel inhibitor; Potassium channel inhibitor; Secreted; Toxin; Vasoactive
References
1 Schweitz H., Vigne P., Moinier D., Frelin C., Lazdunski M.; "A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps)." J. Biol. Chem. 267:13928-13932(1992)
MEDLINE 92332489
PubMed 1352773
Reference Position protein sequence, function, subcellular location, and tissue specificity.
Reference Comment tissue=venom
2 Lisy O., Jougasaki M., Heublein D.M., Schirger J.A., Chen H.H., Wennberg P.W., Burnett J.C.; "Renal actions of synthetic dendroaspis natriuretic peptide." Kidney Int. 56:502-508(1999)
PubMed 10432389
DOI 10.1046/j.1523-1755.1999.00573.x
Reference Position function.
3 Collins E., Bracamonte M.P., Burnett J.C. Jr., Miller V.M.; "Mechanism of relaxations to dendroaspis natriuretic peptide in canine coronary arteries." J. Cardiovasc. Pharmacol. 35:614-618(2000)
PubMed 10774793
DOI 10.1097/00005344-200004000-00015
Reference Position function.
4 Lisy O., Lainchbury J.G., Leskinen H., Burnett J.C. Jr.; "Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure." Hypertension 37:1089-1094(2001)
PubMed 11304508
Reference Position function.
5 Chai O.H., Kim E.K., Lee Y.H., Kim J.G., Baik B.J., Lee M.S., Han E.H., Kim H.T., Song C.H.; "Histamine release induced by dendroaspis natriuretic peptide from rat mast cells." Peptides 22:1421-1426(2001)
PubMed 11514023
DOI 10.1016/S0196-9781(01)00483-1
Reference Position function.
6 Best P.J., Burnett J.C., Wilson S.H., Holmes D.R. Jr., Lerman A.; "Dendroaspis natriuretic peptide relaxes isolated human arteries and veins." Cardiovasc. Res. 55:375-384(2002)
PubMed 12123777
DOI 10.1016/S0008-6363(02)00402-9
Reference Position function.
7 Chen H.H., Lainchbury J.G., Burnett J.C. Jr.; "Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide." J. Am. Coll. Cardiol. 40:1186-1191(2002)
PubMed 12354448
DOI 10.1016/S0735-1097(02)02127-7
Reference Position degradation of dnp.
8 Singh G., Kuc R.E., Maguire J.J., Fidock M., Davenport A.P.; "Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure." Circ. Res. 99:183-190(2006)
PubMed 16778132
DOI 10.1161/01.RES.0000232322.06633.d3
Reference Position function, and npr1 binding.
9 Johns D.G., Ao Z., Heidrich B.J., Hunsberger G.E., Graham T., Payne L., Elshourbagy N., Lu Q., Aiyar N., Douglas S.A.; "Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor." Biochem. Biophys. Res. Commun. 358:145-149(2007)
PubMed 17475216
DOI 10.1016/j.bbrc.2007.04.079
Reference Position function, and npr3 binding.
10 Guo H.-S., Yang Y.-Z., Zou Y., Xu J., Cai Z.-X., Qi Q.-H.; "Effects of dendroaspis natriuretic peptide on calcium-activated potassium current and its mechanism." J. Physiol. Sci. 58:1-6(2008)
PubMed 18096107
DOI 10.2170/physiolsci.RP010507
Reference Position function on potassium channel.
Comments
function Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor A (NPR1). Is a poor agonist of the atrial natriuretic peptide receptor B (NPR2). Is not degradated by neutral endopeptidase (NEP / MME). Binds to atrial natriuretic peptide clearance receptor (NPR3 / NPR-C), which may be responsible of the removal of DNP from the circulation. Increases calcium uptake and induces histamine release from rat peritoneal mast cells. Increases calcium- activated potassium current in gastric antral circular smooth muscle cells by increasing cGMP production and activating inositol trisphosphate receptors (IP3Rs).
subcellular location Secreted.
tissue specificity Expressed by the venom gland.
similarity Belongs to the natriuretic peptide family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
PIR A42974; A42974.
GO ; C:extracellular region; IEA:UniProtKB-SubCell.
; F:hormone activity; IEA:InterPro.
; F:potassium channel inhibitor activity; IEA:UniProtKB-KW.
; P:pathogenesis; IEA:UniProtKB-KW.
; P:regulation of blood vessel size; IEA:UniProtKB-KW.
InterPro IPR000663; Natr_peptide.
Pfam PF00212; ANP; 1.
PROSITE PS00263; NATRIURETIC_PEPTIDE; 1.
Features
Key From To Length Description
peptide 1 38 38 Natriuretic peptide.
/FTId=PRO_0000045068.
disulfid 7 23 17 By similarity.
Sequence information
Length: 38 aa, molecular weight 4193 Da, CRC64 checksum BCAD19AB95B52258 
EVKYDPCFGH KIDRINHVSN LGCPSLRDPR PNAPSTSA